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Developmental toxicity of 2-butin-1,4-diol in rats


Book ID
117451304
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
95 KB
Volume
35
Category
Article
ISSN
0278-6915

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2-Butyne-1,4-diol was given to male and female Wistar 1mp:DAK rats by oral gavage for 28 consecutive days in daily doses of 1, 10 or 50 mg kg-' day-'. After 28 days all animals were necropsied. Blood samples were obtained and selected organs were weighed and prepared for histological examination. Tr

Acute toxicity of 2-butyne-1,4-diol in l
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Acute toxicity of 2-butyne-1,4-diol (BYD) was evaluated in laboratory animals. The evaluation involved acute oral and dermal toxicity in rats, dermal and ocular irritation in rabbits and skin sensitization in guinea pigs. The oral L D ~~ values for BYD were 132 mg kg-' in male rats and 176 mg kg-' i