## Abstract **BACKGROUND**: The number of mouse mutants and strains with neural tube closure defects (NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes, and eight βmultifactorialβ strains. **METHODS**: The emerging patterns of mouse NTDs are considered in relati
Developmental eye and neural tube defects in the eye blebs mouse
β Scribed by Jennifer J. Swiergiel; James L. Funderburgh; Monica J. Justice; Gary W. Conrad
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 429 KB
- Volume
- 219
- Category
- Article
- ISSN
- 1058-8388
No coin nor oath required. For personal study only.
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Many mutations cause neural tube closure defects (NTDs, exencephaly or spina bifida) in mice and the gene loci are widely distributed in the mouse genome.
## Abstract __Splotch__ mutant mice develop neural tube defects (NTDs), comprising exencephaly and/or spina bifida, as well as neural crestβrelated defects and abnormalities of limb musculature. Defects in __splotch__ mice result from mutations in __Pax3__, and some human NTDs may also result from
## Abstract The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds 240, including 205 representing specific genes, 30 for unidentified genes, and 9 multifactorial strains. These mutants identify genes needed for embryonic neural tube closure. Reports of 50 new NTD mutan