## Abstract **BACKGROUND**: The number of mouse mutants and strains with neural tube closure defects (NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes, and eight βmultifactorialβ strains. **METHODS**: The emerging patterns of mouse NTDs are considered in relati
Genetic landmarks for defects in mouse neural tube closure
β Scribed by Harris, M. J.; Juriloff, D. M.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 89 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-3709
No coin nor oath required. For personal study only.
β¦ Synopsis
Many mutations cause neural tube closure defects (NTDs, exencephaly or spina bifida) in mice and the gene loci are widely distributed in the mouse genome.
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## Abstract The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds 240, including 205 representing specific genes, 30 for unidentified genes, and 9 multifactorial strains. These mutants identify genes needed for embryonic neural tube closure. Reports of 50 new NTD mutan
## Abstract ## BACKGROUND Neural tube defects (NTDs) are congenital malformations arising mostly from incomplete neural tube closure during early embryogenesis. Most NTDs in humans have a complex etiology, with involvement of both genetic and environmental factors. More than 100 mouse models for h