✦ LIBER ✦

Developmental expression of Rab11, a small GTP-binding protein in Drosophila epithelia

✍ Scribed by Satish Sasikumar; Jagat Kumar Roy

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 673 KB
Volume: 47
Category: Article
ISSN: 1526-954X
DOI: 10.1002/dvg.20441

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Intracellular membrane trafficking regulates a wide variety of developmental processes, including cell and tissue morphogenesis. Here we report developmental expression of Drosophila Rab11, a small GTP‐binding protein, required for both endocytic recycling and exocytosis. Rab11 is expressed in the epithelial cell types of diverse lineages at all developmental stages, beginning from the cellular blastoderm in early embryos to adult primordia and adult tissues, like the columnar epithelia lining male ejaculatory bulb. A robust expression of Rab11 is seen both in the amnioserosa and in the lateral epidermis during embryonic dorsal closure, a morphogenetic event that involves spreading and fusion of the contra‐lateral sides of epidermis. Rab11 mutant embryos fail to display the characteristic morphological changes in these two epithelial tissues during dorsal closure, providing a strong basis to dissect the role of Rab11 in coordinated epithelial sheet movements. genesis 47:32–39, 2009. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Expression of rab GTP-binding proteins d

Expression of rab GTP-binding proteins during oligodendrocyte differentiation in culture

✍ B.P. Bouverat; W.H. Krueger; T. Coetzee; R. Bansal; S.E. Pfeiffer 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB 👁 2 views

Oligodendrocytes (OLs) synthesize and transport vast amounts of proteins and lipids from the cell body to the morphologically and biochemically distinct domains of the myelin membrane. From our prediction that regulators of vesicular transport should be up-regulated at the time of myelin production,

Mapping small GTP-binding proteins on hi

Mapping small GTP-binding proteins on high-resolution two-dimensional gels by a combination of GTP binding and labeling with in situ periodateoxidized GTP

✍ Dr. Lukas A. Huber; Marcus E. Peter 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 636 KB

Mapping small GTP-binding proteins on highresolution two-dimensional gels by a combination of GTP binding and labeling with in situ periodateoxidized GTP -We compared two approaches to identify and map small GTP-binding proteins in combination with high-resolution two-dimensional (2-D) gel electroph

Rap1, a small GTP-binding protein is upr

Rap1, a small GTP-binding protein is upregulated during arrest of proliferation in human keratinocytes

✍ N.J. D'Silva; R.S. Mitra; Z. Zhang; D.M. Kurnit; C.R. Babcock; P.J. Polverini; T 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB 👁 1 views

## Abstract Rap1 is a small GTP‐binding protein (SMG) that exists in two 95% homologous isoforms, rap1A and rap1B. The functions of the rap1 proteins are not well understood. In this report we examined expression and function of rap1 in primary (HOKs) and immortalized (IHOKs) human oral keratinocyt

Molecular cloning of a cDNA for a small

Molecular cloning of a cDNA for a small GTP binding protein, BRho, from the embryo of Bombyx mori and its characterization after expression and purification

✍ Tomohide Uno; Ai Nakasuji; Wajiro Hara; Yasuo Aizono 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 2 views

A cDNA clone encoding a small GTP binding protein (BRho) was isolated from an embryonic cDNA library of Bombyx mori that encoded a polypeptide with 202 amino acids sharing 60-80% similarity with the Rho1 family of GTP binding proteins. The effector site and one of the guanine nucleotide binding site

Rapid arrest of axon elongation by brefe

Rapid arrest of axon elongation by brefeldin A: A role for the small GTP-binding protein ARF in neuronal growth cones

✍ Hess, Douglas T. ;Smith, Deanna S. ;Patterson, Sean I. ;Kahn, Richard A. ;Skene, 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB 👁 2 views

## Members of the ADP-ribosylation factor (ARF) family of small guanosine triphosphatebinding proteins play an essential role in membrane trafficking which subserves constitutive protein transport along exocytic and endocytic pathways within eukaryotic cell bodies. In growing neurons, membrane tra