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Developmental and Tissue-Specific Regulation of the Q10 Class I Gene by DNA Methylation

✍ Scribed by Kenichi Tanaka, Yves Barra, Kurt J. Isselbacher, George Khoury and Gilbert Jay

Book ID
123633233
Publisher
National Academy of Sciences
Year
1986
Tongue
English
Weight
999 KB
Volume
83
Category
Article
ISSN
0027-8424

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## Abstract The Ξ±2(I) collagen gene shows cell type‐specific expression, however, the mechanism behind this specificity remains to be determined. We demonstrate here that transforming growth factor‐beta (TGF‐β)‐mediated induction of Ξ±2(I) collagen gene is regulated by DNA methylation in a cell type