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Cell-specific epigenetic regulation of ChM-I gene expression: Crosstalk between DNA methylation and histone acetylation

✍ Scribed by Tomoki Aoyama; Takeshi Okamoto; Yoshiki Kohno; Kenichi Fukiage; Seiji Otsuka; Moritoshi Furu; Kinya Ito; Yonghui Jin; Satoshi Nagayama; Tomitaka Nakayama; Takashi Nakamura; Junya Toguchida


Book ID
116295887
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
452 KB
Volume
365
Category
Article
ISSN
0006-291X

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Epigenetic regulation of metallothionein
✍ Sarmila Majumder; Huban Kutay; Jharna Datta; Dennis Summers; Samson T. Jacob; Ka πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 623 KB

## Abstract Metallothioneins (MTs) are a group of cysteine‐rich stress response proteins that scavenge reactive oxygen species and heavy metals. Recently, we have shown that MT‐I promoter is methylated and suppressed in some solid and liquid tumors and can be robustly activated following treatment