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Development of Tolerance in Mice to the Sedative Effects of the Neuroactive Steroid Minaxolone Following Chronic Exposure

โœ Scribed by Fiona H Marshall; Sharon C Stratton; Joanne Mullings; Elaine Ford; Stella P Worton; Nigel R Oakley; Russell M Hagan

Book ID
114103330
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
280 KB
Volume
58
Category
Article
ISSN
0091-3057

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Acute administration of lorazepam (0.25 and 0.5 mg/kg) and triazolam (0.075-0.25 mg/kg) significantly reduced the locomotor activity of rats placed in a holeboard for 10 min. Acute injections of lorazepam (0.25 and 0.5 mg/kg) and triazolam (0.05-0.25 mg/kg) also significantly reduced exploration, me