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Development of the contingent tolerance to midazolam in FR30 reinforcement schedule

✍ Scribed by H.B. Ayvaşik; S.C. Fowler; M.J. Kallman

Book ID
118601554
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
161 KB
Volume
9
Category
Article
ISSN
0924-977X

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## Abstract The effect on digit‐symbol substitution (DSST) of duration and extent of exposure to midazolam was studied in seven healthy male volunteers. Individual pharmacokinetic and pharmacodynamic parameters were estimated after a 7·5 mg intravenous bolus dose of midazolam. Subjects then receive