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Development of single-chain variable fragment (scFv) antibodies against hapten benzo[a]pyrene: a binding study

โœ Scribed by Xaver Y. Z. Karsunke; Haifeng Wang; Ekkehard Weber; Michael D. McLean; Reinhard Niessner; J. Christopher Hall; Dietmar Knopp

Book ID
105895736
Publisher
Springer
Year
2011
Tongue
English
Weight
283 KB
Volume
402
Category
Article
ISSN
1618-2650

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## Background The ability of cytosine deaminase (CD) to convert the antifungal agent 5-fluorocytosine (5-FC) into one of the most potent and largely used anticancer compound such as 5-fluorouracil (5-FU) raised considerable interest in this enzyme to model gene or antibody โ€“ directed enzyme-prodrug