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Development of new nucleic acid photoaffinity probes: Synthesis of 4-thiothymine labelled nucleoside analogues

✍ Scribed by Carole Saintomé; Pascale Clivio; Jean-Louis Fourrey; Anne Woisard; Alain Favre

Book ID
104215671
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
279 KB
Volume
35
Category
Article
ISSN
0040-4039

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✦ Synopsis

The new nucleic acid phot~af~nity probes 1 a, 1 b, 2 and 3 in which a 4thiothymine is linked at the end of a variable chain introduced at the C-5 position of deoxyuridine have been constructed.

📜 SIMILAR VOLUMES

Synthesis of 4-Thiothymine Based Photola
Synthesis of 4-Thiothymine Based Photolabels as New Tools for Nucleic Acids Structural Studies in Solution: Formation of Long-Range Photo-Cross-Links within a Hammerhead Ribozyme Domain
✍ Carole Saintomé; Pascale Clivio; Jean-Louis Fourrey; Anne Woisard; Philippe Laug 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 277 KB

The nucleosidic photolabels 2-5, able to form long-range photo-cross-links, have been used to further investigate the tertiary folding of a hammerhead ribozyme domain. These photolabels derive from 2 H -deoxyuridine which is substituted at its C-5 position with a photoactivable 4-thiothymine unit li