## Abstract Conventional methods in fabrication of scaffolds based on polymer/bioceramic composites frequently make use of solution casting then particle leaching. The residues of common organic solvents can get trapped in this technique hence provide safety concerns on final scaffold. In this stud
Development of layered porous poly(l-lactide) for bone regeneration
✍ Scribed by Joo-Eon Park; Mitsugu Todo
- Book ID
- 106395843
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 347 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-2461
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## Abstract The goal of this study was to design a nontoxic scaffold with both composition and microstructure suitable for bone engineering using collagen (Coll), hydroxyapatite (HA), and poly(lactide‐__co__‐ε‐caprolactone) (PLCL). Mineralized type I Coll was produced by direct nucleation of HA par
## Abstract Porous poly(ϵ‐caprolactone‐__co__‐L‐lactide) (P(CL‐__co__‐LA, wt % ca. 5/95) sponges were prepared, coated biomimetically with CaP/apatite, and implanted with noncoated control sponges into rat femur cortical defects and dorsal subcutaneous space. The implants were inspected histologica
## Abstract As reported previously, a porous composite of uncalcined hydroxyapatite (u‐HA) and poly‐DL‐lactide (PDLLA) showed excellent osteoconductivity and biodegradability as a bone substitute in rabbit model. In this study, to investigate the usefulness of this composite as a scaffold loaded wi