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Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

✍ Scribed by Ian Bruce; Mohammed Akhlaq; Graham C. Bloomfield; Emma Budd; Brian Cox; Bernard Cuenoud; Peter Finan; Peter Gedeck; Julia Hatto; Judy F. Hayler; Denise Head; Thomas Keller; Louise Kirman; Catherine Leblanc; Darren Le Grand; Clive McCarthy; Desmond O’Connor; Charles Owen; Mrinalini S. Oza; Gaynor Pilgrim; Nicola E. Press; Lilya Sviridenko; Lewis Whitehead

Book ID
116318738
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
561 KB
Volume
22
Category
Article
ISSN
0960-894X

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## Abstract The PI3K‐AKT pathway can mediate diverse biological responses and is crucial for optimal immune responses and lymphocyte development. Deletion of PI3K subunits or AKT leads to blockage of T‐cell development at the TCR‐β checkpoint. Studies with over‐expression of constitutively activate