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Development of hemangiosarcomas in B6C3F1 mice fed 2-methyl-1-nitroanthraquinone

✍ Scribed by A. S. Krishna Murthy; J. R. Baker; E. R. Smith; G. G. Wade

Publisher: John Wiley and Sons
Year: 1977
Tongue: French
Weight: 548 KB
Volume: 19
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910190116

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✦ Synopsis

Abstract

Subcutaneous hemangiosarcomas developed in 97% of 172 B6C3F^1^ mice of both sexes fed either 0.03% or 0.06% 2‐methyl‐1‐nitroanthraquinone in the diet. There was no significant relationship to dose or sex. In addition, similar vascular tumors occurred in the mesentery of 14 mice. 2‐Methyl‐1‐nitro‐anthraquinone is carcinogenic in B6C3F^1^ mice when given in food. One of 97 control mice had a splenic hemangiosarcoma.

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