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Development of Fluorine-18-Labeled 5-HT 1A Antagonists

✍ Scribed by Lang, Lixin; Jagoda, Elaine; Schmall, Bernard; Vuong, Bik-Kee; Adams, H. Richard; Nelson, David L.; Carson, Richard E.; Eckelman, William C.

Book ID
120011125
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
302 KB
Volume
42
Category
Article
ISSN
0022-2623

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## Abstract Syntheses of labelled versions of 5‐HT~3~ receptor antagonists, Alosetron and Lurosetron, are described. [^14^C]Alosetron was prepared by routes utilizing either Fischer indolisation of an amidohydrazine or palladium‐mediated cyclisation of an aryl enaminone as key steps. ^2^H and ^13^C