Development of Dirhodium(II)-Catalyzed Generation and Enantioselective 1,3-Dipolar Cycloaddition of Carbonyl Ylides
✍ Scribed by David M. Hodgson; Paul A. Stupple; Françoise Y. T. M. Pierard; Agnès H. Labande; Craig Johnstone
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 215 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0947-6539
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## Abstract The first successful example of the enantioselective intermolecular 1,3‐dipolar cycloaddition of a chiral dirhodium(II) catalyst‐associated carbonyl ylide with an aromatic aldehyde dipolarophile is described. The tandem carbonyl ylide formation/cycloaddition reactions of 1‐diazo‐5‐aryl‐
## Dedicated to Professor Wei-Yuan Huang on the occasion of his 85th birthday The 1,3-dipolar cycloaddition of azomethine ylides to electron-deficient alkenes is one of the most powerful methods for the construction of highly substituted pyrrolidine rings. [1] Following early research on the prepa