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Development of chiral stationary phases for high-performance liquid chromatographic separation

✍ Scribed by Mengling Tang; Jing Zhang; Shulin Zhuang; Weiping Liu

Book ID
119382208
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
771 KB
Volume
39
Category
Article
ISSN
0165-9936

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Characterization of liquid chromatographic chiral separation on chiral crown ether stationary phases
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## Abstract Crown ether‐based chiral stationary phases (CSPs) have been known to be quite useful for the liquid chromatographic resolution of racemic compounds containing a primary amino group. Chiral separations on crown ether‐based CSPs are characterized by several factors. In this paper, the str

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Many active drugs are racemic mixtures. Because the two enantiomers of a racemate often cause different pharmacological responses, the use of optically pure isomers is desirable and may be soon required. Cyclodextrin-bonded silica gel can be used as chiral stationary phase (CSP) in liquid chromatogr