We have studied aspirin as a potential chemopreventive for colorectal cancer, completing Phase I studies on aspirin pharmacology and potential biomarker assays (prostaglandins, PGE 2 and PGF 2โฃ and cyclooxygenase modulation) in normal human subjects. These studies have determined the optimal dose of
Development of Cancer Chemopreventive Agents: Oltipraz as a Paradigm
โ Scribed by Kensler, Thomas W.; Groopman, John D.; Sutter, Thomas R.; Curphey, Thomas J.; Roebuck, Bill D.
- Book ID
- 121467711
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 226 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0893-228X
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The term cancerchemoprevention refers to the prevention or prolongation of carcinogenesis by intervention with drugs prior to the malignant (i.e., invasive) stage. The development of chemopreventive drugs is the major objective of the Chemoprevention Branch of the National Cancer Institute. Neoplast
Experimental studies have demonstrated that carcinogenesis is a multistep process in which inappropriate proliferation of cells is a critical determinant. Polyamines support sustained growth and are highly regulated in all cells. The rate limiting enzyme for this pathway is ornithine decarboxylase (