We have studied aspirin as a potential chemopreventive for colorectal cancer, completing Phase I studies on aspirin pharmacology and potential biomarker assays (prostaglandins, PGE 2 and PGF 2␣ and cyclooxygenase modulation) in normal human subjects. These studies have determined the optimal dose of
Clinical pharmacology studies of Oltipraz — A potential chemopreventive agent
✍ Scribed by Nikolay V. Dimitrov; James L. Bennett; Judy McMillan; Marjorie Perloff; Cheryl Meyer Leece; Winfred Malone
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 785 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The stable isotope-labeled compound 3',-3'-dideuteronicotine (nicotine-d2) was used to investigate the disposition kinetics and effects of nicotine administered subcutaneously to 6 smokers. Plasma nicotine-d2 concentrations were measured for 8 h after subcutaneous injection of 4 doses (0.4, 0.8, 1.2
The dose-response relationship and the time course of action of Org 7617, a short acting non-depolarizing neuromuscular blocking agent, were evaluated during thiopentone, fentanyl, halothane and N20 anaesthesia. Neuromuscular transmission was monitored mechanomyographically. The EDs0 and EDg0 were c