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Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting

โœ Scribed by Richard Hargreaves; Juan Camilo Arjona Ferreira; David Hughes; Jos Brands; Jeff Hale; Britta Mattson; Sandy Mills


Book ID
111400083
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
547 KB
Volume
1222
Category
Article
ISSN
0890-6564

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## Abstract ## BACKGROUND The neurokininโ€1 antagonist aprepitant (EMENDโ„ข; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapyโ€induced nausea and vomiting when it is given with a 5โ€hydroxytryptamineโ€3 receptor antagonist and dexamethasone. The current study sought to