## Abstract ## BACKGROUND The neurokininโ1 antagonist aprepitant (EMENDโข; Merck Research Laboratories, West Point, PA) has been shown to reduce chemotherapyโinduced nausea and vomiting when it is given with a 5โhydroxytryptamineโ3 receptor antagonist and dexamethasone. The current study sought to
Prevention of Nausea and Vomiting: Aprepitant, the First Therapeutically Active NK1 Receptor Antagonist
โ Scribed by Karen Nieber; Konrad Schoppmeyer
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 11 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
In a phase I study of BRL43694A, a 5HT3-receptor antagonist, a single dose of 40 micrograms/kg was given to 24 patients. All patients received cytostatic treatment expected to cause nausea and vomiting. During the first 24 h, 12 patients were completely protected from nausea and vomiting, 4 experien
## Abstract ## BACKGROUND. The combination of palonosetron and aprepitant is safe and effective in the prevention of chemotherapyโinduced emesis (CIE). The purpose of this pilot study was to ascertain the effectiveness of 1โday versus 3โday aprepitant in the prevention of acute and delayed nausea
## Background: Palonosetron, a highly selective and potent 5-ht(3) receptor antagonist with a strong binding affinity and a long plasma elimination half-life (approximately 40 hours), has shown efficacy in phase ii trials in preventing chemotherapy-induced nausea and vomiting (cinv) resulting from