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Development of an Mdm2/p53 fluorescence polarization high throughput inhibitor screening assay


Book ID
117659790
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
299 KB
Volume
38
Category
Article
ISSN
0959-8049

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A Fluorescence Polarization Assay for th
✍ Stephen M.G Knight; Naoki Umezawa; Hee-Seung Lee; Samuel H Gellman; Brian K Kay πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 English βš– 85 KB

Improper function of the tumor suppressor protein p53 is a contributing factor in many human cancers. In normal cells, p53 acts to arrest the cell cycle in response to DNA damage or nucleotide depletion. One mechanism of regulating the amount of p53 in the cell is through the action of the Double Mi