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Fluorescence polarization assay and inhibitor design for MDM2/p53 interaction

✍ Scribed by Rumin Zhang; Todd Mayhood; Philip Lipari; Yaolin Wang; James Durkin; Rosalinda Syto; Jennifer Gesell; Charles McNemar; William Windsor


Book ID
108047676
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
184 KB
Volume
331
Category
Article
ISSN
0003-2697

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Improper function of the tumor suppressor protein p53 is a contributing factor in many human cancers. In normal cells, p53 acts to arrest the cell cycle in response to DNA damage or nucleotide depletion. One mechanism of regulating the amount of p53 in the cell is through the action of the Double Mi