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Development of an internal restriction control in the PCR detection of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation

โœ Scribed by DUBREUILLASTRUCCI, R; DAWSON, D; MUNSTER, M


Book ID
123240761
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
1999
Tongue
English
Weight
431 KB
Volume
4
Category
Article
ISSN
1532-8619

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Methylenetetrahydrofolate reductase (MTH
โœ Rady, Peter L.; Tyring, Stephen K.; Hudnall, S. David; Vargas, Trini; Kellner, L ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 36 KB ๐Ÿ‘ 2 views

The polymorphic mutation C677T in the gene of MTHFR is considered a risk mutation for spina bifida and vascular disease. Another common mutation on the MTHFR gene, A1298C, has also been described as another risk mutation. We studied the frequencies of these two mutations on DNA samples from healthy