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Development of an Extended-Release Formulation of Capecitabine Making Use of In Vitro-In Vivo Correlation Modelling

✍ Scribed by Meulenaar, Jelte; Keizer, Ron J.; Beijnen, Jos H.; Schellens, Jan H. M.; Huitema, Alwin D. R.; Nuijen, Bastiaan


Book ID
124149997
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
705 KB
Volume
103
Category
Article
ISSN
0022-3549

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Development of a controlled-released formulation of chlorpheniramine maleate is described, using in vitro/in vivo correlates, according to a process that has been termed "biorelevant dissolution". The process begins with simulations using several possible input rates combined with known disposition