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Development and Internal Validation of an In Vitro-in Vivo Correlation for a Hydrophilic Metoprolol Tartrate Extended Release Tablet Formulation

✍ Scribed by Natalie D. Eddington; Patrick Marroum; Ramana Uppoor; Ajaz Hussain; Larry Augsburger


Book ID
110308392
Publisher
Springer US
Year
1998
Tongue
English
Weight
625 KB
Volume
15
Category
Article
ISSN
0724-8741

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Once-a-day extended-release dosage form
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Defining a quantitative and reliable relationship between in vitro drug release and in vivo absorption is highly desired for rational development, optimization, and evaluation of controlled-release dosage forms and manufacturing process. During the development of a once-daily extended-release (ER) t