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Development of an ELISA to study the polymorphism of dextromethorphan oxidation in a french population

✍ Scribed by J. P. Frèche; S. Dragacci; A. M. Petit; J. P. Siest; M. M. Galteau; G. Siest

Publisher: Springer
Year: 1990
Tongue: English
Weight: 440 KB
Volume: 39
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00280940

No coin nor oath required. For personal study only.

✦ Synopsis

Simple, sensitive and selective enzyme immunoassays (ELISA) for monitoring urinary dextromethorphan and its major metabolite, dextrorphan, were developed. Dextromethorphan and dextrorphan hemisuccinates were linked to bovine serum albumin and specific antisera against each immunogen were raised in rabbits. The sensitivity of the ELISA was high (limit of detection 740 and 600 pg.ml-1 for dextromethorphan and dextrorphan, respectively). Intra- and interassay variation was less than 10%, and cross-reactivity between the two compounds was less than 1%. The ELISA was employed to phenotype 216 French subjects. The frequency of poor metabolizers was 5.1%.

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