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Development of an efficient and low-cost protocol for the manual PNA synthesis by Fmoc chemistry

✍ Scribed by Concetta Avitabile; Loredana Moggio; Luca D. D’Andrea; Carlo Pedone; Alessandra Romanelli


Book ID
104097825
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
154 KB
Volume
51
Category
Article
ISSN
0040-4039

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An efficient and high yielding protocol
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## Abstract magnified image A simple and efficient method has been developed for the synthesis of 3,4‐dihydropyrimidin‐2(1__H__)‐ones by a one‐pot three component cyclocondensation reaction of alkyl acetoacetates, aldehyde, and urea in the presence of a catalytic amount of the reusable catalyst zi