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An efficient and high yielding protocol for the synthesis of substituted dihydropyrimidin-2(1h)-ones and spiro-fused heterocycles by involving tandem reactions

✍ Scribed by D Subhas Bose; MohD. Idrees

Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 262 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440133

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✦ Synopsis

Abstract

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A simple and efficient method has been developed for the synthesis of 3,4‐dihydropyrimidin‐2(1__H__)‐ones by a one‐pot three component cyclocondensation reaction of alkyl acetoacetates, aldehyde, and urea in the presence of a catalytic amount of the reusable catalyst zinc per chlorate hexahydrate, Zn(ClO~4~)~2~.6H~2~O (10 mol %) the scope of this protocol is utilized for the synthesis of mitotic Kinesin EG5 inhibitor monastrol and new class of fused heterobicyclic compounds in high yields.

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