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Development of an accelerated low-pH reversed-phase liquid chromatography column stability test

✍ Scribed by Brian C. Trammell; Cheryl A. Boissel; Christina Carignan; Daniel J. O’Shea; Christopher J. Hudalla; Uwe D. Neue; Pamela C. Iraneta

Book ID
108092118
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
346 KB
Volume
1060
Category
Article
ISSN
1873-3778

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✍ Patrik Petersson; Melvin R. Euerby 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 362 KB

## Abstract The robustness of the popular ‘Tanaka’ LC column characterization protocol has been evaluated by the statistical tools of reduced factorial design, multiple linear regression and principal component analysis. These have shown that in order to obtain reliable and reproducible results, it