Development of acrylic-based copolymers for oral insulin delivery
β Scribed by Aaron C Foss; Takahiro Goto; Mariko Morishita; Nicholas A Peppas
- Book ID
- 117639532
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- French
- Weight
- 146 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0939-6411
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π SIMILAR VOLUMES
## Abstract The objective of this study is to utilize the pH sensitivity of modified carboxymethyl starch (CMS) for oral delivery of insulin. The chemical modification of natural polymers by grafting has received considerable attention in recent years because of the wide variety of monomers availab
In the present study thiol functionalized polymethacrylic acid-polyethylene glycol-chitosan (PCP)-based hydrogel microparticles were utilized to develop an oral insulin delivery system. Thiol modification was achieved by grafting cysteine to the activated surface carboxyl groups of PCP hydrogels (Cy