## Abstract The objective of this study is to utilize the pH sensitivity of modified carboxymethyl starch (CMS) for oral delivery of insulin. The chemical modification of natural polymers by grafting has received considerable attention in recent years because of the wide variety of monomers availab
Oil-based formulations for oral delivery of insulin
β Scribed by Chun-Lei Li; Ying-Jie Deng
- Book ID
- 111769393
- Publisher
- Pharmaceutical Press
- Year
- 2004
- Tongue
- English
- Weight
- 328 KB
- Volume
- 56
- Category
- Article
- ISSN
- 2042-7158
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In the present study thiol functionalized polymethacrylic acid-polyethylene glycol-chitosan (PCP)-based hydrogel microparticles were utilized to develop an oral insulin delivery system. Thiol modification was achieved by grafting cysteine to the activated surface carboxyl groups of PCP hydrogels (Cy
Several attempts have been made for delivering insulin orally utilizing several polymers with varying degrees of effectiveness. A major obstacle associated with polymeric delivery system for protein or polypeptide drugs is the poor retention of the structure and its biological activity of encapsulat