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Development of a Synthesis For a Long-Term Oxazolidinone Antibacterial

โœ Scribed by Choy, Allison; Colbry, Norman; Huber, Christian; Pamment, Michael; Duine, Justin Van

Book ID
126211550
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
102 KB
Volume
12
Category
Article
ISSN
1083-6160

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โœ Braj B. Lohray; Sundarababu Baskaran; B. Srinivasa Rao; B. Yadi Reddy; I. Negesw ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 2 views

Starting from the D-mannitol derivative (I), a straightforward synthesis of the chiral oxazolidines (VII) including precursors (VIIb) and (VIIc) of linezolid and eperezolid is detailed. Furthermore, the azide (VIIb) is converted to linezolid (IX) with thioacetic acid.