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Development of a shaking bioreactor system for animal cell cultures

โœ Scribed by Chao-Min Liu; Li-Na Hong

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
206 KB
Volume
7
Category
Article
ISSN
1369-703X

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โœฆ Synopsis

The feasibility of using shake flasks to culture animal cells was evaluated using various sizes of cylindrical shaped vessels as bioreactors. It was found that conditions can be optimized so that hybridoma, Chinese Hamster Ovary cells, and insect cells can be efficiently cultured in the shaking reactors to cell densities comparable to that obtained with stirred-jar bioreactors, and the system is scalable to larger volumes for the production of recombinant proteins or cell mass production in the laboratory.

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