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Development of a Prostaglandin D2 Receptor Antagonist: Discovery of a New Chemical Lead.

✍ Scribed by Kazuhiko Torisu; Kaoru Kobayashi; Maki Iwahashi; Hiromu Egashira; Yoshihiko Nakai; Yutaka Okada; Fumio Nanbu; Shuichi Ohuchida; Hisao Nakai; Masaaki Toda


Publisher
John Wiley and Sons
Year
2005
Weight
22 KB
Volume
36
Category
Article
ISSN
0931-7597

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A 2A adenosine receptor (AR) antagonists are promising new drugs for the treatment of Parkinson's disease. Further potential therapeutic indications for A 2A AR antagonists include dementias, ischemias, and pain. Potent, selective A 2A AR antagonists have been developed, but their generally low wate