Development of a phase III trial of hematopoietic stem cell transplantation for systemic lupus erythematosus
โ Scribed by Burt, R K; Marmont, A; Arnold, R; Heipe, F; Firestein, G S; Carrier, E; Hahn, B; Barr, W; Oyama, Y; Snowden, J
- Book ID
- 110013649
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 95 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0007-1188
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๐ SIMILAR VOLUMES
## Abstract ## Objective B cells are likely to contribute to the pathogenesis of systemic lupus erythematosus (SLE), and rituximab induces depletion of B cells. The Exploratory Phase II/III SLE Evaluation of Rituximab (EXPLORER) trial tested the efficacy and safety of rituximab versus placebo in p
## Abstract ## Objective Safer and more effective therapies are needed for the treatment of systemic lupus erythematosus (SLE). B lymphocytes have been shown to play fundamental pathogenic roles in SLE, and therefore, elimination of B cells with the use of rituximab may represent a new therapy for