## Abstract ## Objective Safer and more effective therapies are needed for the treatment of systemic lupus erythematosus (SLE). B lymphocytes have been shown to play fundamental pathogenic roles in SLE, and therefore, elimination of B cells with the use of rituximab may represent a new therapy for
A multicenter phase I/II trial of rituximab for refractory systemic lupus erythematosus
โ Scribed by Yoshiya Tanaka; Kazuhiko Yamamoto; Tsutomu Takeuchi; Norihiro Nishimoto; Nobuyuki Miyasaka; Takayuki Sumida; Yoshihito Shima; Kazuki Takada; Isao Matsumoto; Kazuyoshi Saito; Takao Koike
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 482 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1439-7595
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๐ SIMILAR VOLUMES
## Abstract ## Objective B cells are likely to contribute to the pathogenesis of systemic lupus erythematosus (SLE), and rituximab induces depletion of B cells. The Exploratory Phase II/III SLE Evaluation of Rituximab (EXPLORER) trial tested the efficacy and safety of rituximab versus placebo in p
Causes of death were examined for 1,103 systemic lupus erythematosus patients who were followed from 1965 to 1978 at 9 centers that participated in the Lupus Survival Study Group. A total of 222 patients (20%) died. Lupus-related organ system involvement (mainly active nephritis) and infection were