A multicenter study of outcome in systemic lupus erythematosus. ii.

✍ Scribed by Steven Rosner; Dr. Ellen M. Ginzler; Herbert S. Diamond; Max Weiner; Michael Schlesinger; James F. Fries; Cody Wasner; Thomas A. Medsger Jr.; Gayle Ziegler; John H. Klippel; Nortin M. Hadler; Daniel A. Albert; Evelyn V. Hess; George Spencer-Green; Arthur Grayzel; David Worth; Bevra H. Hahn; Eugene V. Barnett

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 585 KB
• Volume: 25
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780250602

✦ Synopsis

Causes of death were examined for 1,103 systemic lupus erythematosus patients who were followed from 1965 to 1978 at 9 centers that participated in the Lupus Survival Study Group. A total of 222 patients (20%) died. Lupus-related organ system involvement (mainly active nephritis) and infection were the most frequent primary causes of death. Causes of death were similar throughout the followup period. Hemodialysis had little impact on the length of survival for patients with nephritis. Active central nervous system disease and myocardial infarction were infrequent causes of death. There were no deaths from malignancy.

Despite a linear improvement in survival rates since the turn of the century (l), mortality in systemic lupus erythematosus (SLE) is still appreciable. In 1964, Kellum and Haserick (2) reported 86 (29%) deaths among 229 patients who were followed for an 1 l-year period. Similarly, in 1970, Estes and Christian