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Development of a non-radioactive endpoint in a modified local lymph node assay

โœ Scribed by T Hariya; M Hatao; H Ichikawa


Book ID
117451405
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
339 KB
Volume
37
Category
Article
ISSN
0278-6915

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Evaluation of an ex vivo murine local ly
โœ Joseph R. Piccotti; Stephanie A. Knight; Kimberly Gillhouse; Mark S. LaGattuta; ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 146 KB

The local lymph node assay (LLNA) is used to assess the skin sensitization potential of chemicals. In the standard assay, mice are treated topically on the dorsum of both ears with test substance for 3 days. Following 2 days of rest, the initiation of the hypersensitivity response is evaluated by in