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Development of non-radio isotopic endpoint of murine local lymph node assay based on 5-bromo-2′-deoxyuridine (BrdU) incorporation

✍ Scribed by Masahiro Takeyoshi; Kanji Yamasaki; Yoshikuni Yakabe; Mineo Takatsuki; Ian Kimber

Book ID
119536966
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
89 KB
Volume
119
Category
Article
ISSN
0378-4274

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The murine local lymph node assay (LLNA) is a well-established alternative to the guinea pig maximization test (GPMT) or Buehler test (BT) for the assessment of the skin sensitizing ability of a drug, cosmetic material, pesticide or industrial chemical. Instead of radioisotope using in this method,