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Development of a new in vivo anaphylactic histamine release assay in rats

✍ Scribed by G.M. Butchko; T.J. Magoc; R.L. Aspinall; A. Nakao

Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
239 KB
Volume
4
Category
Article
ISSN
0165-2478

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Development of a new controlled-release
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Development of a controlled-released formulation of chlorpheniramine maleate is described, using in vitro/in vivo correlates, according to a process that has been termed "biorelevant dissolution". The process begins with simulations using several possible input rates combined with known disposition