Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels-Alder strategy. The b-turn characteristics of molecule 8 were examined by molecular modeling and NMR spectroscopy.
✦ LIBER ✦
Development of a New Family of Conformationally Restricted Peptides as Potent Nucleators of β-Turns. Design, Synthesis, Structure, and Biological Evaluation of a β-Lactam Peptide Analogue of Melanostatin
✍ Scribed by Palomo, Claudio; Aizpurua, Jesus M.; Benito, Ana; Miranda, José Ignacio; Fratila, Raluca M.; Matute, Carlos; Domercq, Maria; Gago, Federico; Martin-Santamaria, Sonsoles; Linden, Anthony
- Book ID
- 120154252
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 572 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0002-7863
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