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Development of a Multi-Kilogram-Scale Synthesis of AZD1283: A Selective and Reversible Antagonist of the P2Y 12 Receptor

✍ Scribed by Andersen, Søren M.; Aurell, Carl-Johan; Zetterberg, Fredrik; Bollmark, Martin; Ehrl, Robert; Schuisky, Peter; Witt, Anette


Book ID
127105975
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
643 KB
Volume
17
Category
Article
ISSN
1083-6160

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✍ An-Chih Chang; Joseph D. Trometer; Philip S. Portoghese 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 222 KB

## Abstract 2‐(3,4‐Dichlorophenyl)‐N‐methyl‐N‐[(1S)‐1‐(3‐isothiocyanatophenyl)‐2‐(1‐pyrrolidinyl)ethyl]acetamide (1, DIPPA) has been previously reported to be an opioid receptor affinity label that produces selective and long‐lasting κ opioid receptor antagonism in mice, High specific activity [^3^