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Development of a Kilogram-Scale Asymmetric Synthesis of a Potent DP Receptor Antagonist

✍ Scribed by Tudge, Matthew; Savarin, Cecile G.; DiFelice, Katherine; Maligres, Peter; Humphrey, Guy; Reamer, Bob; Tellers, David M.; Hughes, Dave


Book ID
111654025
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
909 KB
Volume
14
Category
Article
ISSN
1083-6160

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Development of a Large Scale Asymmetric
✍ Lukin, Kirill; Hsu, Margaret C.; Chambournier, Gilles; Kotecki, Brian; Venkatram πŸ“‚ Article πŸ“… 2007 πŸ› American Chemical Society 🌐 English βš– 104 KB

A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of it