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Development of a Minimal Residual Disease Model for Ovarian Cancer Using Bioluminescence in an Immunocompetent Mouse Model

✍ Scribed by J.K. Chan; J. Baker; J.Y. Shin; A. Beilhack; R. Nishimura; R.S. Negrin


Book ID
113961299
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
51 KB
Volume
107
Category
Article
ISSN
0090-8258

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## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar