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7 INVITED Developing combination therapies for hormone-refractory prostate cancer in a pre-clinical mouse model of the disease

✍ Scribed by C. Abate-Shen; C.W. Kinkade; M. Castillo-Martin; C. Cordon-Cardo


Book ID
119599162
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
56 KB
Volume
6
Category
Article
ISSN
1359-6349

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## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar