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Development of a Large-Scale Synthetic Route to Manufacture (−)-Huperzine A

✍ Scribed by Tudhope, Stephen R.; Bellamy, Julie A.; Ball, Anthony; Rajasekar, Dewakar; Azadi-Ardakani, Manouchehr; Meera, Harihara Subramanian; Gnanadeepam, Jesudoss Mercy; Saiganesh, Ramanathan; Gibson, Frank; He, Linli

Book ID
111925256
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
588 KB
Volume
16
Category
Article
ISSN
1083-6160

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Development of a New Synthetic Route of
Development of a New Synthetic Route of a Non-Peptide CCR5 Antagonist, TAK-779, for Large-Scale Preparation
✍ Ikemoto, Tomomi; Ito, Tatsuya; Hashimoto, Hideo; Kawarasaki, Tadao; Nishiguchi, 📂 Article 📅 2000 🏛 American Chemical Society 🌐 English ⚖ 66 KB

A new large-scalable preparation of TAK-779 (1), a non-peptide CCR5 antagonist, has been developed. The route selection was focused on in the process research. The selective reduction of commercially available benzonitrile derivative (4) as the starting material with sodium bis(2-methoxyethoxy)alumi