Development of a New Synthetic Route of
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Ikemoto, Tomomi; Ito, Tatsuya; Hashimoto, Hideo; Kawarasaki, Tadao; Nishiguchi,
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Article
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2000
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American Chemical Society
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English
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A new large-scalable preparation of TAK-779 (1), a non-peptide CCR5 antagonist, has been developed. The route selection was focused on in the process research. The selective reduction of commercially available benzonitrile derivative (4) as the starting material with sodium bis(2-methoxyethoxy)alumi