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Development of a Hybrid Physiologically Based Pharmacokinetic Model with Drug-Specific Scaling Factors in Rat to Improve Prediction of Human Pharmacokinetics

โœ Scribed by Sayama, Hiroyuki; Komura, Hiroshi; Kogayu, Motohiro; Iwaki, Masahiro


Book ID
121280445
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
757 KB
Volume
102
Category
Article
ISSN
0022-3549

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Physiologically based pharmacokinetic (PBPK) models were developed for design and optimization of liposome therapy for treatment of overdoses of tricyclic antidepressants and local anesthetics. In vitro drug-binding data for pegylated, anionic liposomes and published mechanistic equations for partit