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Development of a highly α-regioselective indium-mediated allylation reaction in water
✍ Scribed by Teck-Peng Loh; Kui-Thong Tan; Jian-Ying Yang; Chao-Li Xiang
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 56 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Linear a homoallylic alcohol adducts were obtained with high regioselectivities in moderate to good yields using allylic indium reagents in the presence of 10 M water. The exceptionally high regioselectivities observed were neither steric nor electronic in origin from the results presented in this paper.
📜 SIMILAR VOLUMES
The preparation of various 1-acyl-1,2-dihydropyridines with high regioselectivity by indium-mediated allylation of the corresponding 1-acylpyridinium salts is demonstrated. This is applied to the synthesis of (±)-dihydropinidines.
1,1-Trifluoro-4-bromobut-2-ene / Aldehydes / Tin / Indium / Water The indium-mediated allylation reaction of aldehydes with 4-high regio-and excellent diastereoselectivities were obtained. bromo-1,1,1-trifluoro-2-butene in water afforded β-trifluoromethylated homoallylic alcohols in high yields. In