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Development of a fed-batch culture process for enhanced production of recombinant human antithrombin by Chinese hamster ovary cells

✍ Scribed by Kuwae, Shinobu; Ohda, Toyoo; Tamashima, Hiroshi; Miki, Hideo; Kobayashi, Kaoru

Book ID
119949113
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
512 KB
Volume
100
Category
Article
ISSN
1389-1723

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Improved production of recombinant human
Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression
✍ Tomoshi Ohya; Tetsuji Hayashi; Eriko Kiyama; Hiroko Nishii; Hideo Miki; Kaoru Ko πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 260 KB πŸ‘ 2 views

## Abstract To improve the production of recombinant human antithrombin III (AT‐III) in Chinese hamster ovary (CHO) cells, the genes encoding transcription factors, ATF4 (activating transcription factor 4) and XBP‐1s (the spliced form of X‐box binding protein 1), which were involved in the mammalia